Morphofunctional features of the kidneys of rats exposed to low-intensity electromagnetic radiation in the centimeter range in utero

Автор(и)

Ключові слова:

electromagnetic radiation, intrauterine influence, rats, kidneys, blood serum.

Анотація

Background. There are serious disputes about possible damaging effects that radiofrequency electromagnetic radiation (EMR) has on various organs and cells of living organisms. The purpose of the study was to use the results of a histological study of kidney tissue, as well as metabolic indicators of blood serum and kidney tissue of young mature rats exposed to low-intensity EMR in the centimeter range, indicative of necrosis and apoptosis, to identify the possible role of intrauterine factor in postnatal ontogenesis. Methods. In an experimental study on white rats, the effect of EMR before pregnancy and during the bearing of the offspring was simulated. In experimental animals exposed to EMF during intrauterine development, a morphological study of kidney tissue and biochemical parameters in blood serum (LDH activity and sFAS-ligand content) and the level of caspase-3 in kidney tissue was performed. Results. All three indicators notice a significantly increased level of destructive processes in the body in general and in the kidney tissue in particular. Histological signs of glomerular inflammation, atrophy and sclerosis (chronic latent glomerulonephritis) were found in the kidneys of young animals exposed to electromagnetic radiation in utero. Conclusion. This condition is probably related to the general weakness of intracellular regenerative processes in the kidneys and other organs. An assumption is made about the presence of an increased endogenous burden of blood purification during the disposal of the products of cell death in various tissues, as well as with probably reduced capabilities of phagocytes. The juxtaglomerular complex is morphofunctionally more active, and the tubular epithelium wears out quickly.

Посилання

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2022-09-30

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