Роль сигнального шляху Notch у фіброгенезі печінки.

Автор(и)

  • E. I. Lebedeva Витебский государственный медицинский университет, г. Витебск, Республика Беларусь, Білорусь

DOI:

https://doi.org/10.26641/1997-9665.2020.1.7-15

Ключові слова:

сигнальний шлях Notch, фіброз печінки, зірчасті клітини, макрофаги, синусоїдальні ендотеліальні клітини

Анотація

На сучасному етапі предметом інтенсивних досліджень є вивчення механізмів передачі молекулярних сигналів консервативного сигнального шляху Notch в розвитку патологій печінки. В оглядовій статті узагальнено сучасні наукові дані про роль сигнального шляху у фіброгенезі печінки. Аналіз літератури свідчить, що роль сигнального шляху Notch в регуляції активації зірчастих клітин, гепатоцитів, поляризації макрофагів і його взаємодії з іншими сигнальними шляхами при фіброгенезі повністю не вивчена. Слід зазначити, що вивчення змін активності сигнального каскаду має важливе терапевтичне значення в розробці протоколу лікування фіброзу з використанням нових антифіброзних препаратів.

Посилання

Zhan Z, Chen Y, Duan Y, Li L, Mew K, Hu P, Ren H, Peng M. Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis. Peer J. 2019;7:e6645. doi: 10.7717/peerj.6645

Tao Y, Tian K, Chen J, Tan D, Liu Y, Xiong Y, Chen Z, Tian Y. Network pharmacology-based prediction of the active compounds, potential targets, and signaling pathways involved in danshiliuhao granule for treatment of liver fibrosis. Evid Based Complement Alternat. Med. 2019;2630357. doi: 10.1155/2019/2630357

Adams JM, Jafar-Nejad H. The Roles of Notch signaling in liver development and disease. Biomolecules. 2019;9(10). pii: E608. doi: 10.3390/biom9100608

Morell CM, Strazzabosco M. Notch signaling and new therapeutic options in liver disease. J. Hepatol. 2014;60(4):885-90. doi: 10.1016/j.jhep.2013.11.028

Siebel C, Lendahl U. Notch signaling in development, tissue homeostasis, and disease. Physiol. Rev. 2017;97(4):1235-94. doi: 10.1152/physrev.00005.2017

Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene. 2018;37(24):3229-42. doi: 10.1038/s41388-018-0188-1

Chillakuri CR, Sheppard D, Lea SM, Handford PA. Notch receptor-ligand binding and activation: insights from molecular studies. Semin Cell Dev. Biol. 2012;23(4):421-8. doi: 10.1016/j.semcdb.2012.01.009

Wang XP., Zhou J., Han M., Chen CB., Zheng YT., He XS., Yuan XP. MicroRNA-34a regulates liver regeneration and the development of liver cancer in rats by targeting Notch signaling pathway. Oncotarget. 2017;8(8):13264-76. doi: 10.18632/oncotarget.14807

Zhang Y, Li D, Feng F, An L, Hui F, Dang D, Zhao Q. Progressive and prognosis value of Notch receptors and ligands in hepatocellular carcinoma: a systematic review and meta-analysis. Sci. Rep. 2017;7(1):14809. doi: 10.1038/s41598-017-14897-6

Mao Y, Tang S, Yang L, Li K. Inhibition of the Notch signaling pathway reduces the differentiation of hepatic progenitor cells into cholangiocytes in biliary atresia. Cell Physiol. Biochem. 2018;49(3):1074-82. doi: 10.1159/000493290

Chen Y, Zheng S, Qi D, Zheng S, Guo J, Zhang S, Weng Z. Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats. PLoS One. 2012;7(10):e46512. doi: 10.1371/journal.pone.0046512

Morell CM, Fiorotto R, Meroni M, Raizner A, Torsello B, Cadamuro M, Spagnuolo G, Kaffe E, Sutti S, Albano E, Strazzabosco M. Notch signaling and progenitor/ductular reaction in steatohepatitis. PLoS One. 2017;12(11):e0187384. doi: 10.1371/journal.pone.0187384

Nijjar SS, Wallace L, Crosby HA, Hubscher SG, Strain AJ. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am. J. Pathol. 2002;160(5):1695-703.

Gilbert M.A., Spinner N.B. Alagille syndrome: Genetics and Functional Models. Curr. Pathobiol. Rep. 2017;5:233-41. doi: 10.1007/s40139-017-0144-8

Lee SJ, Kim KH, Pak SC, Kang YN, Yoon GS, Park KK. Notch signaling affects biliary fibrosis via transcriptional regulation of RBP-jκ in an animal model of chronic liver disease. Int. J. Clin. Exp. Pathol. 2015;8(10):12688-97

Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology. 2012;55(1):233-43. doi: 10.1002/hep.24631

Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015;75(8):1592-602. doi: 10.1158/0008-5472.CAN-14-1493

Geisler F, Strazzabosco M. Emerging roles of Notch signaling in liver disease. Hepatology. 2015;61(1):382-92. doi: 10.1002/hep.27268

He W, Dai C. Key fibrogenic signaling. Curr. Pathobiol. Rep. 2015;3(2):183-92.

Hu B, Phan SH. Notch in fibrosis and as a target of anti-fibrotic therapy. Pharmacol. Res. 2016;108:57-64. doi: 10.1016/j.phrs.2016.04.010

Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF. Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling. World J. Gastroenterol. 2015;21(3):878-87. doi: 10.3748/wjg.v21.i3.878

Liu C, Liu L, Chen X, Cheng J, Zhang H, Zhang C, Shan J, Shen J, Qian C. LSD1 stimulates cancer-associated fibroblasts to drive Notch3-dependent self-renewal of livercancer stem-like cells. Cancer Res. 2018;78(4):938-49. doi: 10.1158/0008-5472.CAN-17-1236

Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010;139(3):987-98. doi: 10.1053/j.gastro.2010.05.005

Li H, Sun S, Lei Q, Lei P, Cai X, Wan C, Shen G. M1-polarized macrophages promote self-renewing phenotype of hepatic progenitor cells with Jagged1-Notch signalling involved: relevance in primary sclerosing cholangitis. J. Immunol. Res. 2018;4807145. doi: 10.1155/2018/4807145

Terada M, Horisawa K, Miura S, Takashima Y, Ohkawa Y, Sekiya S, Matsuda-Ito K, Suzuki A. Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma. Sci. Rep. 2016;6:34691. doi: 10.1038/srep34691

Bansal R, van Baarlen J, Storm G, Prakash J. The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis. Sci. Rep. 2015;5:18272. doi: 10.1038/srep18272

Xu J, Chi F, Tsukamoto H. Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clin. Res. Hepatol. Gastroenterol. 2015;39(1):24-8. doi: 10.1016/j.clinre.2015.05.016

Morrow D, Hatch E, Hamm K, Cahill PA, Redmond EM. Flk-1/KDR mediates ethanol-stimulated endothelial cell Notch signaling and angiogenic activity. J. Vasc. Res. 2014;51(4):315-24. doi: 10.1159/000367807

Urbanek K, Lesiak M, Krakowian D, Koryciak-Komarska H, Likus W, Czekaj P, Kusz D, Sieroń AL. Notch signaling pathway and gene expression profiles during early in vitro differentiation of liver-derived mesenchymal stromal cells to osteoblasts. Lab. Invest. 2017;97(10):1225-34. doi: 10.1038/labinvest.2017.60

Hao X, Li Y, Wang J, Ma J, Zhao S, Ye X, He L, Yang J, Gao M, Xiao F, Wei H. Deficient O-GlcNAc glycosylation impairs regulatory Т cell differentiation and Notch signalingin autoimmune hepatitis. Front Immunol. 2018;9:2089. doi: 10.3389/fimmu.2018.02089

Duan JL, Ruan B, Yan XC, Liang L, Song P, Yang ZY, Liu Y, Dou KF, Han H, Wang L. Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice. Hepatology. 2018;68(2):677-90. doi: 10.1002/hep.29834

Giovannini C, Bolondi L, Gramantieri L. Targeting Notch3 in hepatocellular carcinoma: molecular mechanisms and therapeutic perspectives. Int. J. Mol. Sci. 2016;18(1). pii: E56. doi: 10.3390/ijms18010056

Lin IY, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT, Chen SC, Pan MH, Ma N. CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways. J. Food Drug. Anal. 2019;27(1):184-94. doi: 10.1016/j.jfda.2018.09.008

Genz B, Coleman MA, Irvine KM, Kutasovic JR, Miranda M, Gratte FD, Tirnitz-Parker JEE, Olynyk JK, Calvopina DA, Weis A, Cloonan N, Robinson H, Hill MM, Al-Ejeh F, Ramm GA. Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells. Sci. Rep. 2019;9(1):8541. doi: 10.1038/s41598-019-44865-1

Liu C, Cheng X, Chen J, Wang Y, Wu X, Tian R, Liu B, Ding X, Sun Q, Gong W. Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration. Theranostics. 2019;9(13):3840-52. doi: 10.7150/thno.33370

Wu N, Nguyen Q, Wan Y, Zhou T, Venter J, Frampton GA, DeMorrow S, Pan D, Meng F, Glaser S, Alpini G, Bai H. The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals. Lab. Invest. 2017;97(7):843-53. doi: 10.1038/labinvest.2017.29

Kim W, Khan SK, Yang Y. Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation. BMB Rep. 2017;50(1):1-2.

Giovannini C, Bolondi L, Gramantieri L. Targeting Notch3 in hepatocellular carcinoma: molecular mechanisms and therapeutic perspectives. Int. J. Mol. Sci. 2016;18(1). pii: E56. doi: 10.3390/ijms18010056

Zhou SJ, Deng YL, Liang HF, Jaoude JC, Liu FY. Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signalingin hepatocellular carcinoma. Cell Death Differ. 2017;24(9):1577-87. doi: 10.1038/cdd.2017.87

Jiang L, Ke M, Yue S, Xiao W, Yan Y, Deng X, Ying QL, Li J, Ke B. Blockade of Notch signaling promotes acetaminophen-induced liver injury. Immunol. Res. 2017;65(3):739-49. doi: 10.1007/s12026-017-8913-3

Sarma NJ, Tiriveedhi V, Subramanian V, Shenoy S, Crippin JS, Chapman WC, Mohanakumar T. Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway. PLoS One. 2012;7(11):e50826. doi: 10.1371/journal.pone.0050826

Ren K, Li T, Zhang W, Ren J, Li Z, Wu G. MiR-199a-3p inhibits cell proliferation and induces apoptosis by targeting YAP1, suppressing Jagged1-Notch signaling in human hepatocellular carcinoma. J. Biomed. Sci. 2016;23(1):79.

Kaylan KB, Berg IC, Biehl MJ, Brougham-Cook A, Jain I, Jamil SM, Sargeant LH, Cornell NJ, Raetzman LT, Underhill GH. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. Elife. 2018;7. pii: e38536. doi: 10.7554/eLife.38536

Luo H, Liu WH, Liang HY, Yan HT, Lin N, Li DY, Wang T, Tang LJ. Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET. Oncotarget. 2018;9(27):18885 95. doi: 10.18632/oncotarget.24421

Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IOL, Yu J, Man K. Oval cells contribute to fibrogenesis of marginal liver grafts under stepwise regulation of aldose reductase and Notch signaling. Theranostics. 2017;7(19):4879-93. doi: 10.7150/thno.20085

Wu CX, Xu A, Zhang CC, Olson P, Chen L, Lee TK, Cheung TT, Lo CM, Wang XQ. Notch inhibitor PF-03084014 inhibits hepatocellular carcinoma growth and metastasis via suppression of cancer stemness due to reduced activation of Notch1-Stat3. Mol. Cancer. Ther. 2017;16(8):1531-43. doi: 10.1158/1535-7163.MCT-17-0001

Lu J, Xia Y, Chen K, Zheng Y, Wang J, Lu W, Yin Q, Wang F, Zhou Y, Guo C. Oncogenic role of the Notch pathway in primary liver cancer. Oncol. Lett. 2016;12(1):3-10.

Gu Y, Xiao L, Ming Y, Zheng Z, Li W. Corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway in vitro and in vivo. Int. J. Oncol. 2016;48(5):1868-76. doi: 10.3892/ijo.2016.3413

##submission.downloads##

Номер

Розділ

Статті