DOI: https://doi.org/10.26641/1997-9665.2020.1.7-15

Роль сигнального шляху Notch у фіброгенезі печінки.

E. I. Lebedeva

Анотація


На сучасному етапі предметом інтенсивних досліджень є вивчення механізмів передачі молекулярних сигналів консервативного сигнального шляху Notch в розвитку патологій печінки. В оглядовій статті узагальнено сучасні наукові дані про роль сигнального шляху у фіброгенезі печінки. Аналіз літератури свідчить, що роль сигнального шляху Notch в регуляції активації зірчастих клітин, гепатоцитів, поляризації макрофагів і його взаємодії з іншими сигнальними шляхами при фіброгенезі повністю не вивчена. Слід зазначити, що вивчення змін активності сигнального каскаду має важливе терапевтичне значення в розробці протоколу лікування фіброзу з використанням нових антифіброзних препаратів.

Ключові слова


сигнальний шлях Notch; фіброз печінки; зірчасті клітини; макрофаги; синусоїдальні ендотеліальні клітини

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Посилання


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Morphologia